Arrestin-β-1 polyclonal antibody

Host: Rabbit   Reactivity: Human,Mouse,Rat

BackGround:Beta Arrestin 1 is a member of a family of proteins thatare widely expressed but especially abundant in the centralnervous system. Serving as an adaptor or scaffoldmolecule, beta Arrestin 1 is essential for mitogenic signaling.Beta Arrestin 1 has important roles in the cytoplasmand at the plasma membrane in the desensitizationand internalization of G protein coupled receptors(GPCRs) and is increasingly appreciated to play an importantrole in the endocytosis and signaling of GPCRs.Beta Arrestin 1 in the cytosol is phosphorylated by ERK1and 2 on serine 412 in a negative feedback mechanismand binds to the phosphorylated receptors at the plasmamembrane.

Product:

Purified mouse monoclonal in buffer containing 0.1MTris-Glycine(pH 7.4 150 mM NaCl)with 0.02% sodium

azide 0.1mg/mlBSA and 50% glycerol.

Molecular Weight:

~ 50 kDa

Swiss-Prot:

P49407

Purification&Purity:

The antibody was affinity-purified from mouse ascites byaffinity-chromatography using epitope-specific immunogen

and the purity is > 95% (by SDS-PAGE).

Applications:

WB: 1:500~1000

Storage&Stability:

Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.

Specificity:

This antibody detects endogenous levels of beta Arrestin1 and does not cross-react with related proteins.

DATA:

Note:

For research use only, not for use in diagnostic procedure.