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Secukinumab 苏金单抗；司库奇尤单抗
生物活性
Secukinumab is a recombinant fully human IgG1/kappa monoclonal antibody. Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor which is expressed in various types of cells, including keratinocytes in skin. Secukinumab (AIN457) is mostly eliminated by being taken up into cells via endocytosis and being broken down inside them.
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km 系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
化学数据
| 分子量 | 147941.89 |
| 分子式 | C6584H10134N1754O2042S44 |
| CAS号 | 875356-43-7 |
| 纯度 | >98% |
| 溶解性（25°C） | |
| 储存和运输条件 | -80°C for long term 常温运输及临时存放 |
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.0068 mL | 0.0338 mL | 0.0676 mL |
| 5 mM | 0.0014 mL | 0.0068 mL | 0.0135 mL |
| 10 mM | 0.0007 mL | 0.0034 mL | 0.0068 mL |
仅供科研使用，不得用于临床检验及治疗使用！