NFkB p100 Polyclonal Antibody
Host: Rabbit Reactivity:Human,Mouse,Rat
BackGround:
NFKB2 appears to have dual functions such as cytoplasmicretention of attached NF-kappa-B proteins by p100and generation of p52 by a cotranslational processing.The proteasome-mediated process ensures the productionof both p52 and p100 and preserves their independentfunction. p52 binds to the kappa-B consensus sequence5'-GGRNNYYCC-3', located in the enhancer region ofgenes involved in immune response and acute phase reactions.p52 and p100 are respectively the minor and majorform; the processing of p100 being relatively poor. Isoformp49 is a subunit of the NF-kappa-B protein complex,which stimulates the HIV enhancer in synergy withp65.
Product:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide,50% glycerol, pH7.2
Molecular Weight:
~ 120 kDa
Swiss-Prot:
Q00653
Purification&Purity:
The antibody was affinity-purified from rabbit antiserumby affinity-chromatography using epitope-specific immunogenand the purity is > 95% (by SDS-PAGE).
Applications:
WB:1:5000~1:10000
Storage&Stability:
Store at 4°C short term. Aliquot and store at -20°C longterm. Avoid freeze-thaw cycles.
Specificity:
NFkB p100 polyclonal antibody detects endogenous levelsof NFkB p100 protein.
DATA:
Note:
For research use only, not for use in diagnostic procedure.